Optimized fluorodendrimer-incorporated hybrid lipid–polymer nanoparticles for efficient siRNA delivery?
Biomaterials Science Pub Date: 2020-01-06 DOI: 10.1039/C9BM01738K
Abstract
Six cationic lipidoid fluorodendrimers are synthesized to construct hybrid lipid–polymer nanoparticles for siRNA delivery. By screening the nanoplatforms including fluorodendrimers with different chemical structures, the optimized nanoparticle NPF13-5 mediates the most efficient silencing of prohibitin 1, inhibition of cell proliferation, and induction of cell apoptosis towards A549 lung adenocarcinoma cells.
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Journal Name：Biomaterials Science
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CAS no.: 89640-58-4
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