A simple and efficient one-pot synthesis of 2-alkyl/aryl/pyridyl substituted 2H-chromenes?
New Journal of Chemistry Pub Date: 2015-07-07 DOI: 10.1039/C5NJ01377A
Abstract
A simple and efficient protocol is demonstrated to synthesize medicinally significant new 2-pyridyl/aryl/alkyl substituted 2H-chromenes. The construction of these chromene systems was through a chemoselective Knoevenagel condensation/hemiketalisation process. The reaction afforded a variety of products in good to excellent yields. This methodology has potential applications in the synthesis of biologically and medicinally relevant molecules. For the first time we have synthesized 2-pyridyl/aryl substituted 2H-chromenes in a one-pot reaction.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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