One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides?

New Journal of Chemistry Pub Date: 2013-01-14 DOI: 10.1039/C3NJ40912K

Abstract

An efficient one-pot reaction of acid chlorides, terminal acetylenes, sodium azide and aryl halides is developed for the regioselective synthesis of 2,4,5-trisubstituted 1,2,3-triazoles. The method is general, convenient, eco-friendly, atom-economical, and could provide excellent yields and regioselectivities.

Graphical abstract: One-pot synthesis of 2,4,5-trisubstituted 1,2,3-triazoles through the cascade reactions of acid chlorides, terminal acetylenes, sodium azide and aryl halides
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