One-pot sequential reaction to 2-substituted-phenanthridinones from N-methoxybenzamides?
Organic & Biomolecular Chemistry Pub Date: 2017-04-25 DOI: 10.1039/C7OB00649G
Abstract
The sequential use of a hypervalent iodine reagent leads to the one-pot synthesis of 2-bromo/chloro-phenanthridinones via an amidation of arenes followed by a regioselective halogenation reaction. These consecutive C–H functionalization reactions can be used efficiently to construct 2-substituted-phenanthridinones at room temperature with good to high yields. Application of the current method is highlighted by the concise synthesis of the natural product PJ34.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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