Oily core/amphiphilic polymer shell nanocapsules change the intracellular fate of doxorubicin in breast cancer cells
Journal of Materials Chemistry B Pub Date: 2019-05-02 DOI: 10.1039/C9TB00587K
Abstract
The aim of this work was to develop and test the in vitro biological activity of nanocapsules loaded with a doxorubicin (DOX) free base dissolved in a core of castor oil shelled by poly(methyl vinyl ether-co-maleic anhydride) conjugated to n-octadecylamine residues. This system was stable and monodisperse, with a hydrodynamic diameter of about 300 nm. These nanocapsules changed the intracellular distribution of DOX, from the nuclei to the cytoplasm, and exhibited higher toxicity towards cancer cells – 4T1 and MCF-7 – and significantly lower toxicity towards normal cells – NIH-3T3 and MCF-10A – in vitro. In conclusion, these nanocapsules are suitable DOX carriers, which remain to be studied in in vivo tumor models.
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Journal Name：Journal of Materials Chemistry B
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CAS no.: 89640-58-4
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