A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates?

Organic & Biomolecular Chemistry Pub Date: 2014-11-10 DOI: 10.1039/C4OB02248C

Abstract

A generalised, simple and efficient synthesis of N-acetyl-5-bromo-4-chloroindoxyl and related analogues required for the synthesis of indigogenic substrates to probe for biological activities is reported. The method is both synthetically and operationally simple and represents a significant improvement on existing methods.

Graphical abstract: A simple and robust preparation of N-acetylindoxyls: precursors for indigogenic substrates
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