Pd(OAc)2 catalyzed direct arylation of electron-deficient arenes without ligands or with monoprotected amino acid assistance?

Chemical Communications Pub Date: 2012-09-06 DOI: 10.1039/C2CC34949C

Abstract

An efficient arylation of electron-poor arenes has been developed without the addition of external ligands or in the presence of a catalytic monoprotected amino acid which assisted the reaction to proceed under mild conditions. The meta-selectivity was observed under both conditions.

Graphical abstract: Pd(OAc)2 catalyzed direct arylation of electron-deficient arenes without ligands or with monoprotected amino acid assistance
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