Palladium(0)-catalyzed direct C–H hetero-arylation of 2-arylimidazo [1,2-a]pyridines with (E)-1-(5-bromothiophen-2-yl)-3-arylprop-2-en-1-ones and their anticancer activity?
RSC Advances Pub Date: 2015-09-15 DOI: 10.1039/C5RA15078G
Abstract
An efficient palladium(0)-catalyzed direct hetero-arylation of imidazo[1,2-a]pyridines at the C-3 position of the imidazole ring has been described. All the synthesized compounds 3a–3r were evaluated for their anticancer activity against a panel of four human cancer cell lines and among all the compounds, 3d, 3j, 3k, 3p and 3r showed promising activity at <10 μM.
![Graphical abstract: Palladium(0)-catalyzed direct C–H hetero-arylation of 2-arylimidazo [1,2-a]pyridines with (E)-1-(5-bromothiophen-2-yl)-3-arylprop-2-en-1-ones and their anticancer activity](http://scimg.chem960.com/usr/1/C5RA15078G.jpg)
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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