Novel bis-cyclic guanidines as potent membrane-active antibacterial agents with therapeutic potential?
Chemical Communications Pub Date: 2017-10-11 DOI: 10.1039/C7CC07285F
Abstract
We designed a class of small dimeric cyclic guanidine derivatives which display potent antibacterial activity against both multidrug-resistant Gram-negative and Gram-positive bacteria. They could compromise bacterial membranes without developing resistance, inhibit biofilms formed by E. coli, and exhibit excellent in vivo activity in the MRSA-infected thigh burden mouse model.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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