NIS-mediated oxidative arene C(sp2)–H amidation toward 3,4-dihydro-2(1H)-quinolinone, phenanthridone, and N-fused spirolactam derivatives?

Organic & Biomolecular Chemistry Pub Date: 2019-06-19 DOI: 10.1039/C9OB01277J

Abstract

A new radical-mediated intramolecular arene C(sp2)–H amidation of 3-phenylpropanamides or [1,1′-biphenyl]-2-carboxamides was developed to prepare a series of 3,4-dihydro-2(1H)-quinolinone and phenanthridone derivatives in moderate to excellent yields (33–94%). Spirolactams could also be obtained using this protocol.

Graphical abstract: NIS-mediated oxidative arene C(sp2)–H amidation toward 3,4-dihydro-2(1H)-quinolinone, phenanthridone, and N-fused spirolactam derivatives
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