New catalytic properties of iron complexes: dehydration of amides to nitriles?

Chemical Communications Pub Date: 2009-07-13 DOI: 10.1039/B910145D

Abstract

Various iron carbonyl clusters such as Fe2(CO)9 or [Et3NH][HFe3(CO)11] are shown to catalyze the dehydration of amides into the corresponding nitriles in the presence of silanes in high yields; this novel protocol showed good functional group tolerance and wide substrate scope.

Graphical abstract: New catalytic properties of iron complexes: dehydration of amides to nitriles
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