Preparation and evaluation of sulfur-containing metal chelators

Organic & Biomolecular Chemistry Pub Date: 2003-10-21 DOI: 10.1039/B307399H

Abstract

With a view to probe the structure and function of G-protein coupled receptors the synthesis of functionalized 8-mercaptoquinoline derivatives and 2-(2-pyridyl)thiophenol was achieved. A fluorescence-based method for determining the affinity of these metal chelators toward zinc ions was developed.

Graphical abstract: Preparation and evaluation of sulfur-containing metal chelators
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