Molecularly imprinted cavities template the macrocyclization of tetrapeptides?

Chemical Communications Pub Date: 2008-09-29 DOI: 10.1039/B813439A

Abstract

Cavities formed using cyclic tetrapeptides (CTPs) or heat-induced conformers act as templates for cyclization; the cavities bind to linear tetrapeptides and enforce turn conformations to enhance cyclization to constrained CTPs.

Graphical abstract: Molecularly imprinted cavities template the macrocyclization of tetrapeptides
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