Phosphinic acid-promoted addition reaction of isocyanides to (Z)-hydroximoyl chlorides: efficient synthesis of α-(hydroxyimino)amides?
Organic & Biomolecular Chemistry Pub Date: 2015-10-30 DOI: 10.1039/C5OB02032H
Abstract
The reaction of (Z)-hydroximoyl chlorides with isocyanides promoted by phosphinic acid in the presence of triethylamine proceeds smoothly to afford α-(hydroxyimino)amides in good to high yields. Phosphinic acid plays an important role in effectively promoting the reaction. A wide range of (Z)-hydroximoyl chlorides and isocyanides were found to be suitable for this reaction.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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