Pd(0)-Catalyzed intramolecular arylative dearomatization of β-naphthols?
Chemical Communications Pub Date: 2017-06-13 DOI: 10.1039/C7CC04022A
Abstract
An efficient Pd(0)-catalyzed intramolecular arylative dearomatization of β-naphthols is described. Using Q-Phos as a ligand, the arylative dearomatization reaction proceeded smoothly affording excellent yields and chemoselectivity even when the catalyst loading was reduced to 0.1 mol%. This method offers an efficient access to a series of structurally diverse spirocarbocycles. Preliminary investigation indicates that an enantioselective reaction is feasible in the presence of a chiral phosphoramidite ligand.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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