Metal-free regioselective C–H chalcogenylation of coumarins/(hetero)arenes at ambient temperature?
Chemical Communications Pub Date: 2020-01-11 DOI: 10.1039/C9CC09001K
Abstract
A novel, practical and metal-free approach for the regioselective selenation of coumarins employing (bis(trifluoroacetoxy)iodo)benzene (PIFA) at room temperature is presented. The developed method is suitable for a wide substrate scope and affords 3-selenyl coumarins in good to excellent yields with high selectivity. A radical mechanism is proposed for this new transformation. Furthermore, the application of sulfenylation with coumarines and selenation with other (hetero)arenes in this transformation is successful.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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