Metal-free regioselective C-3 acetoxylation of N-substituted indoles: crucial impact of nitrogen-substituent?
RSC Advances Pub Date: 2015-06-24 DOI: 10.1039/C5RA10428A
Abstract
A metal-free method for the regioselective C-3 acetoxylation of the N-substituted indoles with PhI(OAc)2 is described under mild reaction conditions. This method tolerates a broad range of functional groups with moderate to good yields. The π-electron-deficient aryl-substituents on the N-atom of indoles and the acidic reaction medium remarkably favor C-3 acetoxylation.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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