Metal- and solvent-free synthesis of aniline- and phenol-based triarylmethanes via Br?nsted acidic ionic liquid catalyzed Friedel-Crafts reaction?
RSC Advances Pub Date: 2021-06-30 DOI: 10.1039/D1RA03724B
Abstract
A beneficial, scalable and efficient methodology for the synthesis of aniline-based triarylmethanes has been established through the double Friedel-Crafts reaction of commercial aldehydes and primary, secondary or tertiary anilines using Br?nsted acidic ionic liquid as a powerful catalyst, namely [bsmim][NTf2]. This protocol was successfully performed under metal- and solvent-free conditions with a broad range of substrates, giving the corresponding aniline-based triarylmethane products in good to excellent yields (up to 99%). In addition, alternative aromatic nucleophiles such as phenols and electron-rich arenes were also studied using this useful approach to achieve a diversity of triarylmethane derivatives in high to excellent yields.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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