One-step protecting-group-free synthesis of azepinomycin in water?
Organic & Biomolecular Chemistry Pub Date: 2015-02-03 DOI: 10.1039/C5OB00210A
Abstract
We report an efficient, atom economical general acid–base catalyzed one-step multi-gram synthesis of azepinomycin from commercially available compounds in water. We propose that the described pH-dependent Amadori rearrangement, which couples an amino-imidazole and simple sugar, is of importance as a potential step toward predisposed purine nucleotide synthesis at the origins of life.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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