Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener?

New Journal of Chemistry Pub Date: 2019-03-18 DOI: 10.1039/C9NJ01072F

Abstract

A stable primary-alkyl-substituted selenenic acid was developed as a synthetic model of selenocysteine–derived selenenic acid (Sec–SeOH) by taking advantage of a huge cavity-shaped substituent. The primary-alkyl model compound was successfully applied to model studies on the trapping reaction of protein Sec–SeOH generated in the active site of selenoenzymes with several reagents.

Graphical abstract: Model study on trapping of protein selenenic acids by utilizing a stable synthetic congener
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