Micelle promoted multicomponent synthesis of 3-amino alkylated indoles via a Mannich-type reaction in water?
RSC Advances Pub Date: 2012-11-30 DOI: 10.1039/C2RA22428C
Abstract
An efficient micelle promoted one-pot synthesis of 3-amino alkylated indoles has been developed via a three-component Mannich-type reaction from secondary amines, aldehydes and indoles in water under mild reaction conditions. In this Mannich-type reaction, micelles stabilize iminium ions, which undergo a nucleophilic addition of the indole to give 3-amino alkylated indoles in very good yields.
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Journal Name：RSC Advances
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