Nickel-catalyzed Suzuki–Miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids?
Organic & Biomolecular Chemistry Pub Date: 2015-06-09 DOI: 10.1039/C5OB01016K
Abstract
An unprecedented highly stereoselective example of nickel-catalyzed Suzuki–Miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids was developed. The reaction proceeded efficiently in the presence of 5 mol% NiCl2(PCy3)2 and K3PO4, affording the Z-fluorostyrene derivatives in good to high yields with excellent regioselectivity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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