Pd-catalyzed double C–H bond activation of diaryl ketones for the synthesis of fluorenones?

Chemical Communications Pub Date: 2012-08-02 DOI: 10.1039/C2CC34344D

Abstract

An efficient synthesis of fluorenones from diaryl ketones by Pd-catalyzed oxidative cyclization is described. A possible mechanism involving a carbonyl group assisted ortho-C–H activation and cyclometalation followed by a second C–H activation to form a six-membered palladacycle and reductive elimination is proposed.

Graphical abstract: Pd-catalyzed double C–H bond activation of diaryl ketones for the synthesis of fluorenones
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