Oligonucleotides containing a piperazino-modified 2′-amino-LNA monomer exhibit very high duplex stability and remarkable nuclease resistance?
Chemical Communications Pub Date: 2015-02-03 DOI: 10.1039/C5CC00322A
Abstract
Incorporation of a piperazino-modified 2′-amino-LNA monomer (PipLNA-T) into oligonucleotides conferred very high affinity and base-pairing selectivity towards complementary DNA and RNA strands. Furthermore, one PipLNA-T modification provided a robust nuclease resistance that safeguarded three neighbouring natural nucleosides from 3′-exonucleolytic degradation. These favourable properties render PipLNA-T a promising oligonucleotide modification for various biological applications.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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