Oxidative cross-coupling of pyridine N-oxides and ethers between C(sp2)–H/C(sp3)–H bonds under transition-metal-free conditions?

Organic & Biomolecular Chemistry Pub Date: 2015-03-10 DOI: 10.1039/C5OB00237K

Abstract

A novel and efficient method based on the cross-coupling reactions of pyridine N-oxides with ethers between C(sp2)–H/C(sp3)–H bonds in the presence of TBHP was developed. The strategy provides an alternative approach to the pyridine moiety under transition-metal-free conditions.

Graphical abstract: Oxidative cross-coupling of pyridine N-oxides and ethers between C(sp2)–H/C(sp3)–H bonds under transition-metal-free conditions
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