A practical ortho-acylation of aryl iodides enabled by moisture-insensitive activated esters via palladium/norbornene catalysis?
Organic Chemistry Frontiers Pub Date: 2020-09-21 DOI: 10.1039/D0QO00982B
Abstract
A novel ortho-arene C–H acylation of aryl iodides catalyzed by the palladium/norbornene cooperative system by employing triazine esters has been developed, leading to the synthesis of polysubstituted aryl ketones. This ortho-acylation even proceeds smoothly in water. Preliminary mechanistic experiments indicate that the strong electron-withdrawing ability and coordination chemistry of triazine play crucial roles in this transformation.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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