Organic base-promoted enantioselective electrophilic cyanation of β-keto esters by using chiral phase-transfer catalysts?
Organic & Biomolecular Chemistry Pub Date: 2015-07-29 DOI: 10.1039/C5OB01301A
Abstract
Highly enantioselective cyanation of β-keto esters using hypervalent iodine(III) as the electrophilic cyanating reagent induced by cinchona alkaloid-based chiral quaternary ammonium salt was demonstrated. Organic bases, especially DMAP, in the chiral phase-transfer catalysis were used to obtain high ees.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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