Iridium-catalyzed enantioselective addition of an N-methyl C–H bond to α-trifluoromethylstyrenes via C–H activation?
Chemical Communications Pub Date: 2021-10-15 DOI: 10.1039/D1CC05076A
Abstract
The Ir-catalyzed enantioselective addition of an N-methyl C–H bond of 2-(methylamino)pyridine derivatives to α-trifluoromethylstyrenes proceeded via C–H activation to give chiral γ-branched amine derivatives having a trifluoromethyl-substituted stereocenter. It was found that a bulky and electron-withdrawing group at the 3-position of 2-(methylamino)pyridines was necessary for the present C–H addition reaction catalyzed by a cationic iridium/chiral bisphosphine complex.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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