Nickel-catalyzed C–H direct amination of benzoxazoles with secondary amines?

Organic & Biomolecular Chemistry Pub Date: 2012-03-15 DOI: 10.1039/C2OB25425E

Abstract

In this article, a facile, efficient and practical method for Ni-catalyzed direct C–H amination of benzoxazole with secondary amines has been developed. This procedure requires Ni(OAc)2·4H2O as catalyst, TBHP as oxidant and acid as the additive. A variety of substituted benzoxazol-2-amines were synthesized in moderate to good yields.

Graphical abstract: Nickel-catalyzed C–H direct amination of benzoxazoles with secondary amines
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