Near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium for hydrogen peroxide detection?
Analytical Methods Pub Date: 2018-07-12 DOI: 10.1039/C8AY01403E
Abstract
A new near-infrared and lysosome-targetable fluorescent probe based on phenoxazinium was designed and prepared for hydrogen peroxide detection. This probe used phenoxazinium as the fluorophore acceptor and a methyl(phenyl)sulfane unit as the recognition group through a photoinduced electron transfer mechanism. With the addition of H2O2, the methyl(phenyl)sulfane unit of the probe was oxidized to a sulfoxide unit, causing enhanced fluorescence intensity at 676 nm due to the inhibition of photoinduced electron transfer. This probe not only showed competitive sensitivity, good selectivity, and a relatively fast response time, but also selectively targeted lysosomes of HeLa cells, indicating that it could be applied to detecting and visualizing H2O2 in HeLa cell lysosomes.
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Journal Name：Analytical Methods
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CAS no.: 89640-58-4
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