Lactoferrin-modified nanoparticles loaded with potent antioxidant Mn-porphyrins exhibit enhanced antioxidative activity in vitro intranasal brain delivery model
Journal of Materials Chemistry B Pub Date: 2017-02-03 DOI: 10.1039/C6TB02599D
Abstract
In this study, for efficient intranasal brain delivery, we have prepared lactoferrin (Lf)-modified nanoparticles loaded with an amphiphilic Mn-porphyrin derivative, MndMImP3P (MnP) (Lf-NP-MnP). MndMImP3P was loaded into the nanoparticles with good loading efficiency. The stability of the resulting Lf-NP-MnP was sufficient for intranasal brain delivery. Lf on the surface of Lf-NP-MnP was significantly recognized by the Lf receptor, which leads to enhanced cellular uptake of MnP and efficient transcytosis. Furthermore, Lf-NP-MnP exhibited antioxidative activity in vitro experiment using a transwell assay as a model of intranasal brain delivery. Our result in this study is one step forward for efficient brain delivery of Mn-porphyrin derivatives to cure neurodegenerative diseases.
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Journal Name：Journal of Materials Chemistry B
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CAS no.: 89640-58-4
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