Novel synthesis of benzotriazolyl alkyl esters: an unprecedented CH2 insertion?

RSC Advances Pub Date: 2021-02-17 DOI: 10.1039/D0RA10413B

Abstract

We have developed a novel method for the synthesis of benzotriazolyl alkyl esters (BAEs) from N-acylbenzotriazoles and dichloromethane (DCM) under mild conditions. This reaction is one of few examples to show the use of DCM as a C-1 surrogate in carbon–heteroatom bond formation and to highlight the versatility of using DCM as a methylene building block.

Graphical abstract: Novel synthesis of benzotriazolyl alkyl esters: an unprecedented CH2 insertion
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