Kinetic resolution of donor-functionalised tertiary alcohols by Cu–H-catalysed stereoselective silylation using a strained silicon-stereogenic silane?

Organic & Biomolecular Chemistry Pub Date: 2008-02-29 DOI: 10.1039/B802186D

Abstract

A series of propargylic tertiary alcohols decorated with an sp2-hybridised nitrogen donor were kinetically resolved by reagent-controlled dehydrogenative Si–O coupling with a strained, highly reactive silicon-stereogenic cyclic silane.

Graphical abstract: Kinetic resolution of donor-functionalised tertiary alcohols by Cu–H-catalysed stereoselective silylation using a strained silicon-stereogenic silane
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