A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis

Organic & Biomolecular Chemistry Pub Date: 2005-07-27 DOI: 10.1039/B503778F

Abstract

In this paper we wish to report on a variety of expedient chemical transformations and purifications achieved via a generic ‘catch and release’ methodology, based on a synthetically inert bipyridyl chelating tag that can be selectively captured with a resin-bound copper(II) species. Utilising this approach we are able to derive many of the same benefits associated with both solid phase synthesis and supported reagent methods.

Graphical abstract: A phase-switch purification approach for the expedient removal of tagged reagents and scavengers following their application in organic synthesis
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