A novel multicomponent microwave-assisted synthesis of 5-aza-adenines?

RSC Advances Pub Date: 2013-06-28 DOI: 10.1039/C3RA41932K

Abstract

A novel multicomponent strategy for the efficient synthesis of 5-aza-adenines was developed. 5-Aza-adenines were prepared in a one-pot fashion from 5-amino-1,2,4-triazoles, cyanamide and triethyl orthoformate under microwave irradiation. The operational simplicity, efficiency and accessibility of this method make it highly attractive for the generation of bioactive compound libraries.

Graphical abstract: A novel multicomponent microwave-assisted synthesis of 5-aza-adenines
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