Hydroxylation of anilides by engineered cytochrome P450BM3?
Organic & Biomolecular Chemistry Pub Date: 2017-10-03 DOI: 10.1039/C7OB02236K
Abstract
Biocatalytic direct monohydroxylation of anilides has been achieved on preparative scale using mutant cytochrome P450BM3 enzymes. Representative mono- and disubstituted N-trifluoromethanesulfonyl anilides are shown to be converted in most cases to the corresponding 4-hydroxy derivatives, with substituent hydroxylation also occurring in two cases. By mutation variation, it is possible to achieve selective hydroxylation of either ring- or side-chain sites.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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