Iron-catalyzed aerobic oxidative functionalization of sp3 C–H bonds: a versatile strategy for the construction of N-heterocycles?

Catalysis Science & Technology Pub Date: 2015-01-14 DOI: 10.1039/C4CY01618A

Abstract

Iron-catalyzed aerobic oxidative functionalization of sp3 C–H bonds has been developed for the construction of N-heterocycles from easily available carboxylic acid derivatives and o-substituted anilines. This transformation represents a widely applicable protocol to N-heterocycles using biofriendly iron as a catalyst in combination with molecular oxygen or air as the sole oxidant.

Graphical abstract: Iron-catalyzed aerobic oxidative functionalization of sp3 C–H bonds: a versatile strategy for the construction of N-heterocycles
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