A novel method for copper(ii) mediated region-selective bromination of aromatic rings under mild conditions?
RSC Advances Pub Date: 2016-06-10 DOI: 10.1039/C6RA13215D
Abstract
A tridentate N2O donor Schiff base is used as the substrate and copper(II) perchlorate and potassium bromide have been used as reagents. In the resulting copper(II) Schiff base complex, the 4 position of the aromatic ring of the Schiff base moiety is brominated. X-ray single crystal diffraction study confirms the structure of the complex. In the conventional bromination of aromatic substrates with bromine as the reagent, a potential pollutant hydrobromic acid is produced as a by-product. The present method provides an alternative environmentally friendly route for the bromination of an activated aromatic ring. Regioselectivity of the bromination in the ligand have been studied using DFT calculations.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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