Late-stage diversification of biologically active pyridazinones via a direct C–H functionalization strategy?
Organic & Biomolecular Chemistry Pub Date: 2014-10-22 DOI: 10.1039/C4OB02061H
Abstract
Divergent C–H functionalization reactions (arylation, carboxylation, olefination, thiolation, acetoxylation, halogenation, naphthylation) using a pyridazinone moiety as an internal directing group were successfully established. This approach offers a late-stage, ortho-selective diversification of a biologically active pyridazinone scaffold. Seven series of novel pyridazinone analogues were synthesized conveniently as the synthetic precursors of potential sortase A (SrtA) inhibitors.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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