Hypervalent iodine: a powerful electrophile for asymmetric α-functionalization of carbonyl compounds

Organic & Biomolecular Chemistry Pub Date: 2014-04-22 DOI: 10.1039/C4OB00318G

Abstract

Environmentally friendly hypervalent iodine reagents are unusually effective promoters of asymmetric α-functionalization of carbonyl compounds. By using hypervalent iodine reagents, various substituents can be introduced into the α-position of carbonyl compounds. In the present review, we briefly survey the asymmetric α-functionalization of carbonyl compound reactions catalyzed by these hypervalent iodine reagents.

Graphical abstract: Hypervalent iodine: a powerful electrophile for asymmetric α-functionalization of carbonyl compounds
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