Glycosylation with glycosyl N-phenyltrifluoroacetimidates (PTFAI) and a perspective of the future development of new glycosylation methods

Chemical Communications Pub Date: 2010-05-26 DOI: 10.1039/C0CC00563K

Abstract

The glycosyl N-phenyltrifluoroacetimidates (PTFAI) have within the last ten years been applied in the synthesis of a wide variety of the oligosaccharides and glycoconjugates. Especially, these donors are found advantageous in glycosidic coupling with ‘a(chǎn)rming’ sugar donors, ketose donors, and with less nucleophilic acceptors. A comprehensive review of the PTFAI donors is provided in a hope to reflect from a particular angle the current status and future trend of the glycosylation chemistry.

Graphical abstract: Glycosylation with glycosyl N-phenyltrifluoroacetimidates (PTFAI) and a perspective of the future development of new glycosylation methods
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