In situ generation of ammonia for the copper-catalyzed synthesis of primary aminoquinolines

New Journal of Chemistry Pub Date: 2014-03-03 DOI: 10.1039/C4NJ00046C

Abstract

The synthesis of primary aminoquinolines from iodoquinolines was carried out in the presence of copper(I) iodide and formamide as the solvent and source of ammonia generated in situ. The reaction proceeded under mild conditions within a few hours and was applicable to various iodoquinolines.

Graphical abstract: In situ generation of ammonia for the copper-catalyzed synthesis of primary aminoquinolines
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