A novel H2S releasing-monastrol hybrid (MADTOH) inhibits L-type calcium channels?
New Journal of Chemistry Pub Date: 2020-12-08 DOI: 10.1039/D0NJ04415F
Abstract
A new alleged monastrol-H2S releasing hybrid, named MADTOH, was designed based on the structure of monastrol (M) and 5-(4-hydroxyphenyl)-3H-1,2-dithiole-3-thione (ADTOH) and synthesized in 7.8% overall yield. MADTOH was shown to be an H2S donor under physiological conditions. In addition, the hybrid causes a decrease in global calcium transient in cardiomyocytes similar to nifedipine (NIFE), taken as a positive control. Whole-cell voltage-clamp showed that MADTOH decreases L-type Ca2+ current in isolated ventricular cardiomyocytes.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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