A nickel catalyzed acceptorless dehydrogenative approach to quinolines?
Organic & Biomolecular Chemistry Pub Date: 2017-12-05 DOI: 10.1039/C7OB02670F
Abstract
A general, efficient and environmentally benign, one-step synthesis of substituted quinoline derivatives was achieved by acceptorless dehydrogenative coupling of o-aminobenzylalcohols with ketones and secondary alcohols catalyzed by a cheap, earth abundant and easy to prepare nickel catalyst [Ni(MeTAA)], featuring a tetraaza macrocyclic ligand (tetramethyltetraaza[14]annulene (MeTAA)). A wide variety of substituted quinolines were synthesized in high yields starting from readily available o-aminobenzylalcohols and ketones or secondary alcohols. A few controlled reactions were carried out to establish the acceptorless dehydrogenative nature of the reactions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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