A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation–cyclization sequence?

Chemical Communications Pub Date: 2013-10-22 DOI: 10.1039/C3CC47927G

Abstract

A novel arylation–cyclization strategy for the highly enantioselective synthesis of titled heterocycles with a quaternary stereogenic center has been developed.

Graphical abstract: A new versatile approach to synthesise enantioenriched 3-hydroxyoxindoles, 1,3-dihydroisobenzofuran and 3-isochromanone derivatives by a rhodium-catalyzed asymmetric arylation–cyclization sequence
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