I2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles?
Chemical Communications Pub Date: 2019-06-18 DOI: 10.1039/C9CC04254G
Abstract
An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been developed. Simple and commercially available starting materials, a broad substrate scope, and excellent functional group tolerability make this strategy practical for applications. Furthermore, 1,2,3-thiadiazole synthesis was realized by using potassium thiocyanate as an odorless sulfur source.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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