A natural product-like inhibitor of NEDD8-activating enzyme?

Chemical Communications Pub Date: 2011-01-14 DOI: 10.1039/C0CC04927A

Abstract

The natural product-like 6,6″-biapigenin has been identified as only the second inhibitor of NEDD8-activating enzyme using virtual screening. This compound was active in enzyme and cell-based assays, with potency in the micromolar range.

Graphical abstract: A natural product-like inhibitor of NEDD8-activating enzyme
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