Highly efficient and practical synthesis of functionalized 1,5-dienes via Pd(ii)-catalyzed halohomoallylation of alkynes?

RSC Advances Pub Date: 2013-05-24 DOI: 10.1039/C3RA41690A

Abstract

A Pd-catalyzed coupling of alkynes with homoallyl alcohols in ionic liquids has been reported, providing a practical, efficient, and versatile method for the synthesis of functionalized (1E)- or (1Z)-1,5-dienes in moderate to good yields. This reaction represents a rare instance of direct homoallylation of homoallyl alcohols.

Graphical abstract: Highly efficient and practical synthesis of functionalized 1,5-dienes via Pd(ii)-catalyzed halohomoallylation of alkynes
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