Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis?
RSC Medicinal Chemistry Pub Date: 2020-08-06 DOI: 10.1039/D0MD00203H
Abstract
Visceral leishmaniasis (VL) affects millions of people across the world, largely in developing nations. It is fatal if left untreated and the current treatments are inadequate. As such, there is an urgent need for new, improved medicines. In this paper, we describe the identification of a 6-amino-N-(piperidin-4-yl)-1H-pyrazolo[3,4-d]pyrimidine scaffold and its optimization to give compounds which showed efficacy when orally dosed in a mouse model of VL.
![Graphical abstract: Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis](http://scimg.chem960.com/usr/1/D0MD00203H.jpg)
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Journal Name：RSC Medicinal Chemistry
research_products
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CAS no.: 89640-58-4
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