Heat- or light-induced acylarylation of unactivated alkenes towards 3-(α-acyl) indolines?
Organic & Biomolecular Chemistry Pub Date: 2020-07-08 DOI: 10.1039/D0OB01105C
Abstract
A heat- or photoredox/iron dual catalysis-enabled dehydrogenative acylarylation of N-allyl anilines leading to 2-substituted 3-(α-acyl) indolines with a quaternary stereogenic center is presented, with unactivated alkenic bonds as radical acceptors and simple aldehydes as radical precursors. This reaction features high yields, a broad substrate scope, and a great exo selectivity, and gram-scale syntheses could be readily carried out.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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